中文

Personnel

Chao-Yong YANG

Posted：2011-11-09  Visits：

Professor
Office: LU Jia-xi Building 532　
Tel: 2187601　
Email: cyyang@xmu.edu.cn
Address: State Key Laboratory of Physical Chemistry of Solid Surfaces

Brief Introduction

  • EDUCATION：

    • B.S., 1998, Xiamen University;

    • M.S., 2001, Xiamen University;

    • Ph.D., 2006, University of Florida, U.S.A.

  • EMPLOYMENT:

    • Postdoctoral Researcher, Department of Chemistry, University of California，Berkeley, U.S.A. (2006.9-2007.12)

    • Professor, Department of Chemical Biology, Xiamen University, (2008.1- ) 

Research Interests

  • Special physicalchemical phenomena in mciroscale and microfluidic chips.

  • Special wetability on the solid surfaces.

  • Micro/nano fabrication techniques and its application in life science.

 

 

Representative Publications

  1. Song, Y; Zhang, W; An, Y; Cui, L; Chen, X; Zhu, Z*; Yang, C*， Label-Free Visual Detection of Nucleic Acids in Biological Samples with Single-Base Mismatch Detection Capability, Chem. Commun., 2011, DOI:10.1039/C1CC15777A

  2. Cui, L; Lin, X; Lin, N; Song, Y; Zhu, Z; Yang, C*， Graphene Oxide -ProtectedDNA Probesfor Multiplex MicroRNA Analysis in Complex Biological Samples Based on Cyclic Enzymatic Amplification Method, Chem. Commun., 2011, DOI:10.1039/C1CC15412E. (Inside Cover)

  3. Wang, X; Zhou, T, Song, X; Jiang, Y; Yang, C, Chen, X； Chameleon clothes for quantitative oxygen imaging， J. Mater. Chem., 2011, 21, 17651.

  4. Shigdar, S;Ward, A; De, A; Yang, C; Wei, M; Duan， W, Clinical Applications of Aptamers and Nucleic Acid Therapeutics in Haematological Malignancies, British Journal of Haematology, 2011, 155,3-13.

  5. Tan, W; Wang, H;Chen, Y; Zhang, X; Zhu, H; Yang, C; Yang, R., Molecular aptamers for drug delivery, Trends in Biotechnology, 2011,doi:10.1016/j.tibtech.2011.06.009.

  6. Yang, C.*; Cui, L.; Huang, J.;Yan, L.; Lin, X.; Wang, C.; Zhang, W.; Kang, H; Linear Molecular Beacons for Highly SensitiveBioanalysis Based on Cyclic Exo III EnzymaticAmplification, Biosensors and Bioelectronics, 2011, 29, 119-124.

  7. Song, Y.; Cui, L.; Wu, J.;Zhang, W.; Kang, H.; Yang, C.*, Allosteric Molecular Beacons for Sensitive Detection of Nucleic Acids, Proteins and Small Molecules in Complex Biological Samples, Chem.-Eur. J., 2011,17, 9042-9046.(Inside Cover)

  8. Lin, H.; Zou, Y.; Huang, Y.; Chen, J.; Zhang, W.; Zhuang, Z.; Jenkins, G.; Yang, C.*; DNAzymeCrosslinkedHydrogel: ANew Platform for Visual Detection of Metal Ions, Chem. Commun., 2011, 47, 9312–9314.(Back Cover)

  9. Fang, X.; Cai, Y.; Liu, J.; Wang, Z.; Wu, Q.; Zhang, Z.; Yang, C.; Yuan, L.; Ouyang, G.*；Twist2 contributes to breast cancer progression by promoting anepithelial-mesenchymal transition and cancer stem-like cellself-renewal，Oncogene, 2011,doi:10.1038/onc.2011.181.

  10. Wang, K.; You, M.; Chen, Y.; Han, D.; Zhu, Z. Huang, J.;Williams, K.; Yang, C.*; Tan, W.* ; Self-assembly of a Bifunctional DNA Carrier for DrugDelivery, Angew. Chem. Int. Ed Engl. 2011,50, 27,6098–6101.

  11. Wang, X; Song, X.; He, C.; Yang, C. Chen, G.; Chen, X.; Preparation of Reversible Colorimetric Temperature Nanosensors andTheir Application in Quantitative Two-Dimensional Thermo-Imaging; Anal Chem.,2011, 83, 2434–2437.

  12. Wang, C.; Zhu, Z.; Song, Y.; Lin H.; Yang C.*; Tan, W*;Caged molecular beacons: controlling nucleic acid hybridizationwith light, Chem. Commun.,2011,47 (20), 5708 - 5710.

  13. Hu, J.; Wu,J.; Li,C.; Zhu, L.; Zhang,W.; Kong, G.; Lu Z.*; Yang, C.*; A G-quadruplexAptamer Inhibits the Phosphatase Activity of Oncogenic Protein Shp2in vitro, ChemBioChem, 2011, 12, 424 – 430.

  14. Cui, L.; Ke, G.; Zhang, W.; Yang, C.*; A Universal Platform for Sensitive and Selective Colorimetric DNA Detection Based on Exo III Assisted Signal Amplification, Biosensors and Bioelectronics, 2011,26, 2796–2800.

  15. Huang, J.; Wu, Y.; Chen, Y.;, Zhu, Z.; Yang, X.; Yang, C.*; Wang, K.*; Tan, W.*; PyreneExcimer Probes for Nucleic Acids in Complex Biological Fluids Based on Hybridization Chain Reaction Amplification, Angew. Chem. Int. Ed Engl. 2011,50，401-404.

  16. Wang, C.; Wu ,C.; Chen, Y; Song, Y; Tan, W; Yang, C.*, PyreneExcimer for DNA Sensors, Current Organic Chemistry，2011, 15(4), 465-476.

  17. Chen, Y.; O'Donoghue, M.; Huang, Y.; Kang, H.; Phillips, J.; Chen, X; Estevez, M.; Yang, C.; Tan, W.*，A Surface Energy Transfer Nanoruler for Measuring Binding Site Distances on Live Cell Surfaces, J. Am. Chem. Soc., 2010, 132 (46), 16559–16570.

  18. Li, D.; Guan, Z.; Zhang, W.; Zhou X.; Zhuang, Z.; Wang, X. and Yang, C.* , Synthesis of Uniform-size Hollow Silica Microspheres through Interfacial Polymerization in Monodisperse Water-in-oil Droplets，ACS Applied Materials & Interfaces, 2010, 2(10), 2711-2713.

  19. Wu, C.; Hu, J.; Zou, Y. A.; Wang, C.; Liu, J.*; Yang, C.*. Application of Aptamers in Biomedicine. Progress in Chemistry 2010,22 (8), 1518-1530. (Invited Review)

  20. Ouyang, G.; Wang, Z.; Fang, X. and Yang, C.; Molecular Signaling of the Epithelial to Mesenchymal Transition in Generating and Maintaining Cancer Stem Cells, Cellular and Molecular Life Sciences, 2010, 67, 2605-2618.

  21. Leng, X.; Zhang, W.; Wang, C.; Cui, L,; Yang, C.*, Agarose Droplet Microfluidics for Highly Parallel and EfficientSingle Molecule Emulsion PCR, Lab Chip 2010,10(21),2841-2843. (Inside Cover)，(Top Ten Accessed Paper, 2010 September)

  22. Cui, L.; Ke, G.; Wang, C.;Yang, C.*, A Cyclic Enzymatic Amplification Method for Sensitive and Selective Detection of Nucleic Acids, Analyst. 2010,135，2069-2073.

  23. Wu ,C.; Yan, L.; Wang, C.; Wang, C.; Chen, X.; Yang, C.*, A General Excimer Signaling Approach for Aptamer Sensors, Biosensors and Bioelectronics, 2010, 25(10), 2232-2237.

  24. Zhu, Z.; Wu C.; Liu H.; Zou Y.; Zhang X.; Kang H.; Yang C.*; Tan W.*, Aptamer-Crosslinked Hydrogel as a Colorimetric Platform for Visual Detection. Angew. Chem. Int. Ed Engl. 2010，49（2）1052 –1056.（Frontipiece Paper）

  25. Yang, C.； Tan, W.,Understanding Bioanalytical Chemistry: Principles and Applications. By Victor A. Gault and Neville H. McClenaghan. ChemBioChem, 2010, 11(3), 434.

  26. Wu ,C.; Wang, C.;Yan, L.; Wang, C.; Yang, C.* PyreneExcimer Nucleic Acid Probes forBiomolecule Signaling. J. of Biomed. Nanotech. 2009, 5.495–504.

  27. Zhang, W.; Lin, S.; Wang, C.; Hu, J.; Li, C.; Zhuang, Z.; Zhou, Y.; Mathies, R. A.*; Yang, C.* PMMA/PDMS valves and pumps for disposable microfluidics. Lab Chip 2009,9 (21), 3088-3094.

  28. Wang, K.; Tang, Z.; Yang, C.; Kim, Y.; Fang, X.; Li, W.; Wu, Y.; Medley, C. D.; Cao, Z.; Li, J.; Colon, P.; Lin, H.; Tan, W. Molecular engineering of DNA: molecular beacons. Angew. Chem. Int. Ed Engl. 2009,48 (5), 856-870.

  29. Martinez, K.; Medley, C. D.; Yang, C.; Tan, W. Investigation of the hybrid molecular probe for intracellular studies. Anal. Bioanal. Chem. 2008,391 (3), 983-991.

  30. Kumaresan, P.; Yang, C.; Cronier, S. A.; Blazej, R. G.; Mathies, R. A. High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets. Anal. Chem. 2008,80 (10), 3522-3529.（Cover）(Co-First Author）

  31. Wu, Y.; Yang, C.; Moroz, L. L.; Tan, W. Nucleic acid beacons for long-term real-time intracellular monitoring. Anal. Chem. 2008,80 (8), 3025-3028.

  32. Chen, Y.; Yang, C.; Wu, Y.; Conlon, P.; Kim, Y.; Lin, H.; Tan, W. Light-switching excimer beacon assays for ribonuclease H kinetic study. Chembiochem. 2008,9 (3), 355-359.

  33. Conlon, P.; Yang, C.; Wu, Y.; Chen, Y.; Martinez, K.; Kim, Y.; Stevens, N.; Marti, A. A.; Jockusch, S.; Turro, N. J.; Tan, W. Pyrene excimer signaling molecular beacons for probing nucleic acids. J. Am. Chem. Soc. 2008,130 (1), 336-342.

  34. Kim, Y.; Yang, C.; Tan, W. Superior structure stability and selectivity of hairpin nucleic acid probes with an L-DNA stem. Nucleic Acids Res. 2007,35 (21), 7279-7287.

  35. Yang, C.; Wang, L.; Wu, Y.; Kim, Y.; Medley, C. D.; Lin, H.; Tan, W. Synthesis and investigation of deoxyribonucleic acid/locked nucleic acid chimeric molecular beacons. Nucleic Acids Res. 2007,35 (12), 4030-4041.

  36. Yang, C.; Martinez, K.; Lin, H.; Tan, W. Hybrid molecular probe for nucleic acid analysis in biological samples. J. Am. Chem. Soc. 2006,128 (31), 9986-9987.

  37. Shangguan, D.; Li, Y.; Tang, Z.; Cao, Z. C.; Chen, H. W.; Mallikaratchy, P.; Sefah, K.; Yang, C.; Tan, W. Aptamers evolved from live cells as effective molecular probes for cancer study. Proc. Natl. Acad. Sci. U.S.A 2006,103 (32),11838-11843.

  38. Yang, C.; Li, J. J.; Tan, W. Using molecular beacons for sensitive fluorescence assays of the enzymatic cleavage of nucleic acids. Methods Mol. Biol. 2006,335, 71-81.

  39. Liu, H.; Wang, H.; Shi, Z.; Wang, H.; Yang, C.; Silke, S.; Tan, W.; Lu, Z. TaqMan probe array for quantitative detection of DNA targets. Nucleic Acids Res. 2006, 34 (1), Art. No. E4.

  40. Tan, L.; Li, Y.; Drake, T.; Moroz, L.; Wang, K.; Li, J.; Munteanu, A.; Yang, C.; Martinez, K.; Tan, W. Molecular beacons for bioanalytical applications. Analyst 2005, 130 (7), 1002-1005.

  41. Yang, C.; Medley, C. D.; Tan, W. Monitoring nucleic acids using molecular beacons. Curr. Pharm. Biotechnol. 2005,6 (6), 445-452.

  42. Yang, C.; Jockusch, S.; Vicens, M.; Turro, N. J.; Tan, W. Light-switching excimer probes for rapid protein monitoring in complex biological fluids. Proc. Natl. Acad. Sci. U.S.A 2005,102 (48), 17278-17283.

  43. Wang, L.; Yang, C.; Medley, C. D.; Benner, S. A.; Tan, W. Locked nucleic acid molecular beacons. J. Am. Chem. Soc. 2005,127 (45), 15664-15665.

  44. Yang, C.; Lin, H.; Tan, W. Molecular assembly of superquenchers in signaling molecular interactions. J. Am. Chem. Soc. 2005,127 (37), 12772-12773.

  45. Yang, C.; Pinto, M.; Schanze, K.; Tan, W. Direct synthesis of an oligonucleotide-poly(phenylene ethynylene) conjugate with a precise one-to-one molecular ratio. Angew. Chem. Int. Ed Engl. 2005, 44 (17), 2572-2576.

  46. Bagwe, R. P.; Yang, C.; Hilliard, L. R.; Tan, W. Optimization of dye-doped silica nanoparticles prepared using a reverse microemulsion method. Langmuir 2004,20 (19), 8336-8342.

  47. Wang, L.; Yang, C.; Tan, W. Dual-luminophore-doped silica nanoparticles for multiplexed signaling. Nano Lett. 2005, 5(1), 37-43.

  48. Huang, Z.; Yang, C.; Zhuang, Z.; Wang, X.; Lee, F. S. C. Determination of trace lead in the high salt matrix of comestible CaCO3 by an isotope dilution method with detection by inductively coupled plasma-mass spectrometry. Analytica Chimica Acta 2004, 509 (1), 77-82.