中文

Hao-Hua HUO

Posted:2020-02-03  Visits:


Professor
Office: Room 607, Lujiaxi Building 
Tel: None
Email:hhuo@xmu.edu.cn

Address: State Key Laboratory of Physical Chemistry of Solid Surfaces


Brief Introduction

l   Ph.D., Philipps-Universität Marburg, Marburg, Germany (2016)

l   Post-Doctor, California Institute of Technology, USA (2016-2019)

l   Professor, Xiamen Univ. (2019- )  

Research Interests

Visible-light-induced organic synthesis, Metallaphotoredox catalysis, Transition-metal catalysis, Asymmetric catalysis

Representative Publications

1. H. Huo, B. Gorsline, G. C. Fu*, Catalyst-controlled douly enantioconvergent coupling of racemic alkyl nucleophiles and electrophiles. Science 2020, 367, 559-564.

2. H. Huo, K. Harms, E. Meggers*, “Catalytic, Enantioselective Addition of Alkyl Radicals to Alkenes via Visible-Light-Activated Photoredox Catalysis with a Chiral Rhodium Complex”, J. Am. Chem. Soc. 2016, 138, 6936-6939.

3. H. Huo, C. Wang, K. Harms, E. Meggers*, “Enantioselective, Catalytic Trichloromethylation through Visible-Light-Activated Photoredox Catalysis with a Chiral Iridium Complex”, J. Am. Chem. Soc. 2015, 137, 9551-9554. (featured in Synfacts 2015, 11, 1071;Synform 2015/12, A172-A174)

4. H. Huo, X. Shen, C. Wang, L. Zhang, P. Röse, L.-A. Chen, K. Harms, M. Marsch, G. Hilt, E. Meggers*, “Asymmetric Photoredox Transition-Metal Catalysis Activated by Visible Light”, Nature 2014, 515, 100-103. (News & Views Feature by K. Skubi and T. P. Yoon, Nature 2014, 515, 45-46; Synfacts 2015, 11, 0153; Chem. Eng. News 2014, Nov. 10, p. 9; Nachrichten aus der Chemie 2015, 2, 108 and 3, 283)

5. H. Huo, C. Fu, K. Harms, E. Meggers*, “Asymmetric Catalysis with Substitutionally Labile yet Stereochemically Stable Chiral-at-Metal Iridium(III) Complex”, J. Am. Chem. Soc. 2014, 136, 2990-2993. (“ACS Editors’ Choice”, featured in JACS Spotlights and Synfacts 2014, 10, 0487)

6. H. Huo, E. Meggers*, “Cooperative Photoredox and Asymmetric Catalysis”, Chimia, 2016, 70, 186-191.

7. H. Huo, X. Huang, X. Shen, K. Harms, E. Meggers*, “Visible-Light-Activated Enantioselective Perfluoroalkylation with a Chiral Iridium Photoredox Catalyst”, Synlett, 2016, 27, 749-753.

8. H. Huo, C. Fu, C. Wang, K. Harms, E. Meggers*, “Metal-Templated Enantioselective Enamine/H-bonding Dual Activation Catalysis”, Chem. Commun. 2014, 50, 10409-10411.

9. H.-H. Huo, X. E. Xia, H. K. Zhang, P.-Q. Huang*, “Enantioselective Total Syntheses of (-)-FR901483 and (+)-8-epi-FR901483”, J. Org. Chem. 2013, 78, 455-465.

10. H.-H. Huo, H. K. Zhang, X. E. Xia, P.-Q. Huang*, “A Formal Enantioselective Total Synthesis of FR901483”, Org. Lett. 2012, 14, 4834-4837.

11. X. Shen, H. Huo, C. Wang, B. Zhang, K. Harms, E. Meggers*, “Octahedral Chiral-at-Metal Iridium Catalysts: Versatile Chiral Lewis Acids for Asymmetric Conjugate Additions”, Chem. Eur. J. 2015, 21, 9720-9726.

12. C. Wang, L.-A. Chen, H. Huo, X. Shen, K. Harms, L. Gong, E. Meggers*, “Asymmetric Lewis Acid Catalysis Directed by Octahedral Rhodium Centrochirality”, Chem. Sci. 2015, 6, 1094-1100.

13. C. Wang, Y. Zheng, H. Huo, P. Röse, L. Zhang, K. Harms, G. Hilt, E. Meggers*, “Merger of Visible Light Induced Oxidation and Enantioselective Alkylation with a Chiral Iridium Catalyst”, Chem. Eur. J. 2015, 21, 7355-7359.

14. J. Chen, A. E. Wang, H.-H. Huo, P.-Q. Huang*, “Progress on the Total Synthesis of Natural Products in China: From 2006 to 2010” Sci. China-Chem. 2012, 55, 1175-1212.

15. H. K. Zhang, Z. J. Lin, H. Huang, H.-H. Huo, Y. J. Huang, J. L. Ye, P.-Q. Huang*, “Enantioselective Synthesis of the Diazatricyclic Core of Alkaloid TAN1251C via an Iodoaminocyclization Reaction” Chin. J. Chem. 2010, 28, 1717-1724.