我室杨朝勇教授Angew. Chem. Int. Ed.上发表了题为'Directional Regulation of Enzyme Pathways through the Control of Substrate Channeling on a DNA Origami Scaffold'的研究论文。
相关链接：http://onlinelibrary.wiley.com/doi/10.1002/anie.201603183/full

Abstract

Artificial multi-enzyme systems with precise and dynamic control over the enzyme pathway activity are of great significance in bionanotechnology and synthetic biology. Herein, we exploit a spatially addressable DNA nanoplatform for the directional regulation of two enzyme pathways (G6pDH–MDH and G6pDH–LDH) through the control of NAD+ substrate channeling by specifically shifting NAD+ between the two enzyme pairs. We believe that this concept will be useful for the design of regulatory biological circuits for synthetic biology and biomedicine.