我室高锦豪教授在 Chemistry of Materials 上发表论文：Biodegradable and Renal-Clearable Hollow Porous Iron Oxide Nanoboxes for In Vivo Imaging

文章链接：https://pubs.acs.org/doi/10.1021/acs.chemmater.8b03564

摘要：

For in vivo imaging, it is important that imaging agents could be harmlessly eliminated from the body after performing their functions. Gadolinium-based magnetic resonance contrast agents have been suffering from low relaxivity, a potential risk of gadolinium deposition. The biocompatibility and biodegradability of gamma-Fe2O3 nanoparticles render them promising as a potential candidate contrast agent for MRI applications. Herein, we develop a facile synthesis of biodegradable hollow porous iron oxide nanoboxes (HPIOs) with high r1 values and low r2/r1 ratios, allowing for superior contrast-enhanced T1 imaging. The zwitterionic dopamine sulfonate (ZDS) functionalized HPIOs (HPIOs@ZDS) could effectively avoid nonspecific protein adsorption and achieve controllable biodistribution. Furthermore, HPIOs@ZDS could be degraded into 4-5 nm fragments in the body and subsequently cleared by kidneys rapidly after magnetic resonance imaging, which significantly reduces potential long-term toxicity. These desirable features make HPIOs@ZDS a prominent T1 contrast agent for magnetic resonance angiography in vivo. These biodegradable and biocompatible HPIOs@ZDS holds great promise for highly sensitive and accurate detection of heart and vascular diseases in molecular imaging.