我室徐海超 JACS 教授发表论文：Electrochemical Difluoromethylarylation of Alkynes

文章链接：https://pubs.acs.org/doi/10.1021/jacs.8b00391

摘要：

An unprecedented radical difluoromethylarylation reaction of alkynes has been developed by discovering a new difluoromethylation reagent, CF₂HSO₂NHNHBoc. This air-stable and solid reagent can be prepared in one step from commercially available reagents CF₂HSO₂Cl and NH₂NHBoc. The CF₂H radical, generated through ferrocene-mediated electrochemical oxidation of CF₂HSO₂NHNHBoc, participates in an unexplored alkyne addition reaction followed by a challenging 7-membered ring-forming homolytic aromatic substitution step to afford fluorinated dibenzazepines.