Title: Amidinyl Radical Formation through Anodic N−H Bond Cleavage and Its Application in Aromatic C−H Bond Functionalization

Author: Huai-Bo Zhao,Zhong-Wei Hou,Zhan-Jiang Liu,Ze-Feng Zhou,Dr. Jinshuai Song,Prof. Dr. Hai-Chao Xu

Abstract:

We report herein an atom-economical and sustainable approach to access amidinyl radical intermediates through the anodic cleavage of N−H bonds. The resulting nitrogen-centered radicals undergo cyclizations with (hetero)arenes, followed by rearomatization, to afford functionalized tetracyclic benzimidazoles in a highly straightforward and efficient manner. This metal- and reagent-free C−H/N−H cross-coupling reaction exhibits a broad substrate scope and proceeds with high chemoselectivity.

FULLLINK: http://onlinelibrary.wiley.com/doi/10.1002/anie.201610715/full