Title: Yttrium-Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium-Sized Lactams

Author: Bo Zhou, Long Li, Xin-Qi Zhu, Juan-Zhu Yan, Yi-Lin Guo, Prof. Dr. Long-Wu Ye*

Abstact:

An efficient yttrium-catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium-sized lactams. Furthermore, a mechanistic rationale for this novel cascade reaction is well supported by a variety of control experiments.