Title: Electrochemical Synthesis of Polycyclic N-Heteroaromatics through Cascade Radical Cyclization of Diynes

Authors: Zhong-Wei Hou, Zhong-Yi Mao, Jinshuai Song, and Hai-Chao Xu

Abstract:

An electrochemical cyclization reaction of easily available urea-tethered diynes has been developed for the synthesis of nitrogen-doped polycyclic aromatic hydrocarbons (PAHs). The employment of ferrocene as a mild and selective redox catalyst allows access to a variety of electron-rich PAHs including helicene-like structures without overoxidation. The electrosynthetic method involves an unprecedented amidyl radical cascade cyclization process to form three rings in a single operation.

Full-Link: http://pubs.acs.org/doi/abs/10.1021/acscatal.7b02105